Blood type, the researchers found, stood out as a potential key difference between the two groups. Neutralizing antibodies, interferon-gamma (IFN-), interleukin (IL)-6, CD4+ T-lymphocyte, and B-lymphocyte counts were evaluated in serum samples after stimulation with 2 g/mL SARS-CoV-2 spike protein for 16h at follow-up intervals of 2 months. The full coverage rate of the COVID-19 vaccination program has reached approximately 90% of the population required to be vaccinated in 2022 (10). Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). First there is a reaction in the arm where you are injected - think swelling and soreness - as the immune system swings into gear. xhr.setRequestHeader('Content-Type', 'text/plain;charset=UTF-8'); Glob Health Res Policy (2022) 7:21. doi:10.1186/s41256-022-00255-1, 12. SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy. Participants with documented reverse transcription-polymerase chain reaction-confirmed COVID-19 or those who had been vaccinated with any other vaccine (e.g., influenza or others) or booster vaccine since the primary dose were excluded. Congestion/runny nose. The early response observed 30 days after the second dose showed a boost effect linked to the same manufacturers scheme. One study published by the CDC reports that from March 2020 to January 2021, patients with COVID-19 had nearly 16 times the risk for myocarditis compared with patients who did not have COVID-19. To date, most of the Chinese population has been vaccinated with the inactivated vaccine. Boosting vaccination is considered important, as antibodies and cellular immune responses were reduced in susceptible populations. 2021 Sep 2;17(9):2957-2958. doi: 10.1080/21645515.2021.1922061. 14:1107866. doi: 10.3389/fimmu.2023.1107866. As the study is ongoing, further follow-up data on the third dose of a vaccine booster will be reported in the future. Further inquiries can be directed to the corresponding author. Among them, Beijing Kexing Zhongwei, Beijing Kexing, Beijing Biology, Lanzhou Biology, Wuhan Biology, and Changchun Biology produce the inactivated vaccine type for a vaccination program of two doses at an interval of 38 weeks. N Engl J Med (2020) 383:201829. For a March study out of the Southern University of Science and Technology in Shenzhen, China, scientists tracked the blood types of nearly 2,200 COVID-19 patients in Chinese hospitals, along with those of about 27,000 individuals who didn't have COVID-19 in the same areas. People may start . Both primary and safety analyses included all participants who received two doses of the inactivated vaccine and had suffered local and systemic adverse events for 30 consecutive days after vaccination. While Anderson and colleagues noted their sample was mostly white, with a minority contribution from other ethnicities, they added their results were similar when restricted to white race alone. "Blood group O is significantly associated with reduced susceptibility to SARS-CoV-2. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. Fatigue, headaches, muscle and joint aches and fever are all potential side effects as well. Opens in a new tab or window, Visit us on YouTube. Blood type O seems to have the lowest risk. All analyses, including linear regression, linear mixed models, and adverse effect analysis, were conducted using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) and plotted using Prism 8.0. The results showed that those with A blood types were significantly more likely to contract the coronavirus compared with other blood types. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). 2022 Feb;29(2):555-563. doi: 10.1111/ene.15147. afficher des publicits et des contenus personnaliss en fonction de vos profils de centres dintrt; mesurer lefficacit des publicits et contenus personnaliss; et. 1:38 Syncope following injection 2:36 Primarily headaches 3:37 Clotting disorder after vaccination 4:37 Any neurological events 4:50 Dexamethasone and surgical site infection 5:51 Also had people. Other neurological side effects occur in a much lower frequency. Comment on "SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fiber neuropathy by J. Finsterer. Would you like email updates of new search results? Epub 2021 Aug 28. Vaccine induced immune thrombotic thrombocytopenia causing a severe form of cerebral venous thrombosis with high fatality rate: a case series. Keywords: These quick trivia tidbits will help you kill your boredom and impress your friends. However, this speculation requires validation using a larger patient cohort. When the researchers looked at this second classification, there was further good newspeople in any blood group which is Rh-negative are also "somewhat protected" from the virus. This is why some vaccines require a brief observation period after your shot. In contrast, we observed a decrease in the B-lymphocyte count and IL-6 level on days 1 to 240 in participants stimulated with the SARS-CoV-2 S antigen (B = 0.004, 95% CI 0.005 to 0.003; p = 0.008 and B = 0.004, 95% CI 0.006 to 0.002, p = 0.001, respectively; Tables5, 6; Figures3A, G). Associations were observed between blood type and production of neutralizing antibodies and IFN-. (D) Kinetics of B-lymphocyte count according to age. J Clin Transl Res. Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and -experienced subjects: Impact of booster dose and breakthrough infections. I don't think that having Type A or Type B is the problemit's just that they don't have Type O," says Mark Udden, MD, professor of hematology and oncology at Baylor College of Medicine in Houston. These Type A antibodies might make it more difficult for SARS-CoV-2 to attach to its receptor in Type O blood and multiply in the body, he explains. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. And for more signs you could've contracted the virus, check out If You Have This Symptom, There's an 80 Percent Chance You Have COVID. Opens in a new tab or window, Visit us on Facebook. Most side effects are mild and normally last only a day or two. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. World J Clin Cases. Additional research has buttressed the possibility of a link. (EG) Kinetics of interferon (IL)-6 levels according to (E) age, (F) vaccine manufacturer, (G) occupation and (H) interval between doses of vaccination. Costa Clemens SA, Weckx L, Clemens R, Almeida Mendes AV, Ramos Souza A, Silveira MBV, et al. Of the 107,796 individuals tested for COVID-19, 11,468 patients tested positive. Lancet (2022) 399:5219. An official website of the United States government. The levels of cellular immune molecules, such as IFN- and CD4+ T-lymphocytes, reflect the levels of effector molecules involved in the humoral immune response, such as memory B cells and neutralizing antibodies (26). Dr. Susan R. Bailey, an allergist, immunologist and president of the American Medical Association, said side effects develop because your immune system is reacting to the vaccine. The inactivated vaccine was administered as a single intramuscular injection for each of the two approved doses. The full eligibility criteria were provided in the volunteer recruitment notification distributed through social networks, including WeChat groups. The new study's co-author, Joel Ray, MD, of St. Michael's Hospital, suggested that people with these more resistant blood types may have already developed antibodies that can recognize certain aspects of the novel coronavirus and are therefore better prepared to fight it off. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. Figure1 Study profile. Lancet Respir Med (2021) 9:9991009. Negative blood types are also somewhat protected from the virus. The original contributions presented in the study are included in the article/Supplementary Material. The worst outcome of these side effects is associated with VST, why it should not be missed and treated appropriately in due time. A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. This type of side effect most commonly occurs within the first hour of when the vaccine is given and usually immediately after. Vaccines are safe and effective at lowering the risk of getting sick and dying from COVID-19. Wheatley AK, Juno JA, Wang JJ, Selva KJ, Reynaldi A, Tan HX, et al. Finsterer J. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. The multiple linear regression analysis revealed that participants aged >50 years had lower reactive IFN- levels and B-lymphocyte counts than those aged 1830 years (Tables36, Figures3AG; Tables S8S15) (B = 0.15, p = 0.03; B = 0.04, p = 0.036, respectively) (Tables3, 5; Figures3A, D). Moderna says 9.7% of their participants felt fatigued and 4.5% got . Follow-up visits were scheduled on days 130 to measure vital signs, review any solicited and unsolicited adverse events, and update medical and medication records. In this study, the older population produced lower levels of neutralizing antibodies, IFN-, B-lymphocytes, and IL-6, similar to that in previous studies (3, 25). Federal government websites often end in .gov or .mil. But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. Here is all the latest news about convicted killer, Alex Murdaugh. It varies from person to person, but how dramatic the initial response is does not necessarily relate to the long-term response. We know the Covid virus damages the lining of your blood vessels. Antibody responses to BNT162b2 vaccination in Japan: Monitoring vaccine efficacy by measuring IgG antibodies against the receptor-binding domain of SARS-CoV-2. From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. Borobia AM, Carcas AJ, Prez-Olmeda M, Castao L, Bertran MJ, Garca-Prez J, et al. You experience shortness of breath or swelling of the lips or face. The most common adverse effect was fatigue (n = 4), followed by fever (n = 2), injection site pain (n = 4), malaise (n = 4), rash (n = 4), and pruritus (n = 3). There was no association with blood type and either susceptibility to COVID-19 infection or disease severity in a large cohort study, researchers said. It's normal to experience side effects after the vaccine. 30. This result indicates that by changing the interval between vaccinations with the inactivated vaccine from the current 38 weeks to 610 weeks (12), vaccinated people can produce higher levels of neutralizing antibody. Even DNA testing company 23andMe tapped their customers and found that among 750,000 people who were diagnosed and hospitalized for Covid (this was prior to vaccines), those with type O were more protected. 8 A total of 3 643 918 persons were enrolled in v-safe and completed at least 1 health survey within 7 days following their first vaccine dose; 1 920 872 v-safe participants reported receiving a second vaccine dose and completed at . The side effects mean your body is working hard to build the antibodies and cells it will need to fight the virus, if or when you are exposed to it. Library job allowed him to plan the escape. Si vous ne souhaitez pas que nos partenaires et nousmmes utilisions des cookies et vos donnes personnelles pour ces motifs supplmentaires, cliquez sur Refuser tout. After adjusting for age, sex, occupation, blood type, interval between doses of vaccination, vaccination duration, and BMI, the highest geometric mean concentration (GMC) of neutralizing antibodies was 53.1 IU/mL in the same-manufacturer vaccination group at 1530 days, which was slightly but significantly higher than the 44.6 IU/mL found in the mixed-manufacturer vaccination group (p < 0.001) (Table2; Figure2B). Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. Type O blood, the most common in the U.S., provides some protection against COVID. P=0.11), hospitalization (OR 0.89, 95% CI 0. . People with blood type O may be less vulnerable to Covid-19 and have a reduced likelihood of getting severely ill, according to two studies published Wednesday. Expert Rev Vaccines (2021) 20:13617. doi:10.1016/S0140-6736(22)00770-X, 26. In 2020, scientists started talking about a link between blood type and Covid. } else { Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and variants of concern. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-s-primed participants (CombiVacS): A multicentre, open-label, randomised, controlled, phase 2 trial. 2021;76:e3286. Share on Facebook. Participants with blood type A and workers had lower levels of IFN- than those with blood type B and medical staff, respectively (B = 0.16, 95% CI 0.040.28, p = 0.01 and B = 0.27, 95% CI 0.46 to 0.07, p = 0.008, respectively; Table3; Figures3B, C). if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { Acta Neurol Scand. Prospective cohort of Chinese individuals immunized with the inactivated vaccine and serological assays. Unable to load your collection due to an error, Unable to load your delegates due to an error. "The smaller sample sizes and retrospective, observational nature of many prior studies, in addition to their striking heterogeneity of ABO associations with disease susceptibility and severity, could be due to chance variations, publication bias, differences in genetic background, geography and environment, and viral strains," they wrote. Individuals vaccinated with different vaccines, those with blood type A, and workers had weaker humoral and cellular immune responses to vaccines than those vaccinated with the same vaccine, those with blood type B, and medical staff. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. All rights reserved. Reactogenicity analysis results are presented as percentage of participants. Guillain-Barre syndrome should be monitored upon mass vaccination against SARS-CoV-2. "Reassuring the public that everything is being done . Blood type may influence other infections, as well. . Then, a study published in the New England Journal of Medicine confirmed the idea with a peer-reviewed study: Folks with Type A blood were 45 percent more likely to become infected with Covid than those with other blood types, while those with Type O were 35 percent less likely. In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. Disclaimer. COVID19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey. (19, 20), we divided participants into three BMI groups: <18.5, 18.523.9, and >23.9 kg/cm2. That link was established pretty early on in the pandemic and scientists didn't let it go. HHS Vulnerability Disclosure, Help Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: A sentinel surveillance study. John Quinn is a London-based writer and editor who specializes in lifestyle topics. doi:10.1016/j.vaccine.2020.12.083, 6. Opens in a new tab or window. doi:10.1002/jmv.27825, 10. Participants in the mixed-manufacturer vaccination group, those with an interval of >40 days between doses of vaccination, and workers produced lower levels of IL-6 than those in the same-manufacturer vaccination group, those with an interval of <40 days between doses of vaccination, and medical staff (B = 0.01, 95% CI 0.014 to 0.003, p = 0.003, B = 0.44, 95% CI 0.8 to 0.1, p = 0.019, and B = 1.5, 95% CI 2.1 to 0.9, p < 0.001, respectively; Table6; Figures3FH). But the seemingly-banal detail might be a factor in who is most susceptible to Covid 19. and transmitted securely. Unfolding the determinants of COVID-19 vaccine acceptance in China. Figure3 Quantitation of cell immune responses on days 1240 following administration of the Chinese inactivated vaccine. Opens in a new tab or window, Visit us on LinkedIn. Clinics (Sao Paulo). First-line lorlatinib or crizotinib in advanced ALK-positive lung cancer. Safety of COVID-19 Vaccines Some people have no side effects. Use or keep moving your arm. The most common side effect of the vaccine is temporary soreness and swelling at the injection site. Before They also found non-white race, defined as African American, American Indian/Alaskan Native, Native Hawaiian, or Pacific Islander was associated with viral positivity (13.9% vs 6.9%, respectively) and hospitalization (23.9% vs 11.3%) versus white race. J Med Virol (2022) 94:411524. Vaccination is the most effective measure to reduce mortality from COVID-19 and serious diseases (12); however, vaccines are scarce in certain countries and some regions in China (13). Online ahead of print. All participants provided their informed consent in writing before enrollment. BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers. Other neurological side effects occur in a much lower frequency. mesurer votre utilisation de nos sites et applications. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. doi:10.1111/ane.13451 If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. By February 21, 2021, more than 46 million persons received at least 1 dose of an mRNA-based COVID-19 vaccine. A higher IL-6 level was associated with older age, mixed-manufacturer vaccinations, intervals of less than 40 days between two doses of vaccination, and medical staff. doi:10.1038/s41422-021-00590-x, 23. -, Wang MW, Wen W, Wang N, et al. O is the most common blood type in the U.S.: 37 percent of white Americans fall into this category, according to the American Red Cross, with the numbers rising to 47 percent among African-Americans, 53 percent among Latinx-Americans, and 39 percent of Asian-Americans. COVID-19; SARS-CoV-2; adverse reaction; neuropathy; side effect; vaccination. And for more regular updates on the virus, sign up for our daily newsletter. 38 Articles, This article is part of the Research Topic, https://doi.org/10.3389/fimmu.2023.1107866, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, Creative Commons Attribution License (CC BY). Table5 Factors associated with B-lymphocyte count after the administration of the inactivated Chinese COVID-19 vaccine. The studies involving human participants were reviewed and approved by the ethics committee of Henan Provincial Peoples Hospital. Table2 Factors associated with the neutralization antibody concentration after the administration of the Chinese inactivated COVID-19 vaccine. Wong LP, Alias H, Siaw YL, Muslimin M, Lai LL, Lin Y, et al. doi:10.6061/clinics/2021/e3286 Side effects can be a powerful deterrent stopping people from getting vaccinated. That year, research in the journal .css-16acfp5{-webkit-text-decoration:underline;text-decoration:underline;text-decoration-thickness:0.125rem;text-decoration-color:#d2232e;text-underline-offset:0.25rem;color:inherit;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}.css-16acfp5:hover{color:#000;text-decoration-color:border-link-body-hover;background-color:yellow;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}PLOS Genetics revealed that people with Type A blood are more likely to have a severe case of Covid-19.